49ers vs Colts LIVE Score Updates: Tight game (34-20) | 12/22/2025

TOUCHDOWN! Jonathan Taylor breaks free for a 4-yard touchdown up the middle of the field to close the gap and put pressure on the game. Blake Grupe’s extra point is good, and the Colts are looking to get back into the game.

The fourth quarter is underway at Lucas Oil Stadium with the score 34-20 between the San Francisco 49ers and the Indianapolis Colts. Plenty of excitement is expected in the second quarter of this Week 16 game of the 2025 NFL Regular Season. It’s time to decide the winner.

The 49ers are trying to respond with some good plays in series, but the home defense is well positioned and prevents the visitors from scoring points. They have sent them to fourth down twice, but they are unable to take the ball away to return the Colts’ offense to the field.

We’re still seeing few scoring opportunities. The visitors have possession, but this is a defensive game, with both teams pressing to reach the opposing penalty area. The home team is trying to control the ball, but San Francisco is well-positioned and advancing up the field.

FIELD GOAL! Blake Grupe cuts the deficit for Indianapolis with a 23-yard field goal. The difference is 11 points for the visitors, while the home team salvaged points after a long offensive drive with good opportunities but failed to reach the red zone.

TOUCHDOWN! The 49ers respond immediately, Juan Jennings catches a 7-yard pass from Brock Purdy to tie the game at Lucas Oil Stadium. Eddy Pineiro adds the field goal, bringing the visitors’ total to 7. San Francisco is now just two touchdowns behind.

Several starters are visibly tired, and the rotation of players has begun. Their absence is noticeable for both teams; neither offense has managed to advance beyond midfield, and it seems unlikely they will manage to tie the game. The clock continues its ticking towards the end.

The third quarter begins at Lucas Oil Stadium with the score 24-17 between the San Francisco 49ers and the Indianapolis Colts. Plenty of excitement is expected in the second quarter of this Week 16 game of the 2025 NFL Regular Season. The third quarter promises to be a thrilling affair.

FIELD GOAL! Eddy Pineiro extends the lead for San Francisco with a 23-yard field goal. A slim advantage for the home team, who salvaged points after a long offensive drive with good opportunities but failed to reach the red zone.

We’ve reached the two-minute break at Lucas Oil Stadium. Not much is happening on the pitch, and it looks like the game will go into halftime with these final chances for both teams to try and change the scoreline.

The ball is intercepted and San Francisco regains possession. Brock Purdy leads the visitors’ offense, and they advance strongly, scoring on two drives. A good offensive series with aerial passes and short runs allows them to cross midfield.

We’re still creating plenty of scoring opportunities; both teams have stopped their consecutive scoring drives, but both are pressing to get into the opposing penalty area. The home team is controlling possession, but San Francisco is holding firm and preventing any real danger.

TOUCHDOWN! George Kittle catches a 15-yard pass from Brock Purdy to give the 49ers back the lead on the scoreboard. The extra point is good, and San Francisco pulls ahead at Lucas Oil Stadium for second time.

The 49ers are in the red zone and are relentlessly pushing forward, looking to add more points to their tally and extend their lead in the standings. Their passing game has been a highlight for San Francisco, and they’re determined to avoid a punt before the end of the quarter.

TOUCHDOWN! A 26-yard pass from Philip Rivers finds Alec Pierce again on the left sideline, opening the scoring at Lucas Oil Stadium. Blake Grupe kicks the field goal, making it 7 for the home team. Indianapolis ties the game.

The second quarter is underway at Lucas Oil Stadium with the score 14-7 between the San Francisco 49ers and the Indianapolis Colts. Plenty of excitement is expected in the second quarter of this Week 16 game of the 2025 NFL Regular Season. There will be some great moments in the second quarter.

A good few minutes of play have passed; both teams have come out with more energy and are eager to add more points. The scoreboard has already changed in this period, but the game has quickly shifted; the home team, despite the score remaining the same, looks better, and now it’s the 49ers who are forced to step up their game.

Indy tried to respond with some good plays, but the visiting defense was well-positioned and prevented the Colts from scoring more points. They had been sent to fourth down twice, but they were unable to take the ball back and return the 49ers’ offense to the field.

TOUCHDOWN! The 49ers respond immediately, Demarcus Robinson catches a 22-yard pass from Brock Purdy to tie the game at Lucas Oil Stadium. Eddy Pineiro adds the field goal, giving the visitors a 7-0 lead. It’s all square on the gridiron.

TOUCHDOWN! A 20-yard pass from Philip Rivers finds Alec Pierce on the left sideline, opening the scoring at Lucas Oil Stadium. Blake Grupe makes the field goal, bringing the visitors’ total to 7. Indianapolis takes the lead.

A great start on the gridiron, the Colts with the first possession of the ball and trying to open the scoring. The visiting defense was well positioned to prevent this and recover the ball for their offense, keeping the score at zero.

The Week 16 game of the 2025 NFL Regular Season between the San Francisco 49ers and the Indianapolis Colts is underway at Lucas Oil Stadium. Follow all the action of this great matchup here  on  VAVEL.

We are just minutes away from the start of the game presentation, the teams’ entrance, and the pre-game protocols for the 2025 NFL Regular Season for this Week 16 matchup between the San Francisco 49ers and Indianapolis Colts at Lucas Oil Stadium.

Lucas Oil Stadium is set to host the San Francisco 49ers and Indianapolis Colts for Week 16 of the 2025 NFL Regular Season. A win is needed to climb the standings and maintain their position at the top of their respective conferences. A large crowd is expected, with a significant portion of the tickets sold before kickoff.

Cameron Filipe will be the center referee for this game between the San Francisco 49ers and Indianapolis Colts as part of Week 16 of the 2025 NFL Regular Season, which will take place at Lucas Oil Stadium.

The NFL Regular Season is underway, and both teams are looking to secure a crucial victory as they prepare for the 2025 regular season kickoff. Both teams are among the best in their respective leagues, and a win would be vital in further strengthening their chemistry and their pursuit of the championship.

The last time these two teams faced off was in the 2023 NFL season when the San Francisco 49ers won at Paycor Stadium by a score of 27-15, thanks to a great performance by Keyton Marshall, who threw two touchdown passes and totaled 107 passing yards.

Today we have a very interesting game between the San Francisco 49ers and the Indianapolis Colts, with both teams looking for a win to continue their preparations for the 2025 NFL season and get off to a good start in the league and compete for their goals.

We’re just under an hour away from kickoff between the San Francisco 49ers and Indianapolis Colts at Lucas Oil Stadium for the 2025 NFL Regular Season. Both teams will be looking for the win. Who will come out on top this time? Follow our coverage on VAVEL.

Here are the start times for the San Francisco 49ers vs. Indianapolis Colts game on December 22, 2025, in various countries:
Argentina: 10:15 PM (NFL League Pass)
Bolivia: 9:15 PM (NFL League Pass)
Brazil: 10:15 PM (NFL League Pass)
Chile: 10:15 PM (NFL League Pass)
Colombia: 8:15 PM (NFL League Pass)
Ecuador: 7:15 PM (NFL League Pass)
USA (ET): 8:15 PM (NFL League Pass)
Spain: 2:15 AM (NFL League Pass)
Mexico: 7:15 PM (NFL League Pass)
Paraguay: 10:15 PM (NFL League Pass)
Peru: 8:15 PM (NFL League Pass)
Uruguay: 10:15 PM (NFL League Pass)
Venezuela: 9:15 PM (NFL League Pass)
If you want to follow it online, VAVEL is your best option.

These are the players currently on the team’s injured list: None. Despite having several players with serious injuries, the Colts have a number of key players available on their roster and are working on a significant rotation to avoid further injuries. An additional absence could be announced for the game up until the last minute.

The Colts’ quarterback continues his journey this season with the sole mission of further developing in the NFL and becoming a key player in the team’s aspirations. The Indianapolis native is the team’s offensive leader. His stats this season include 3,505 passing yards, 28 touchdown passes, and 6 interceptions, contributing to 10 wins. The game against the Bills will be a great test to begin showcasing what this team is capable of in its quest to reach the Super Bowl. The quarterback’s connection with Jonathan Taylor will be crucial for a successful season.

The Indianapolis Colts continue their season in the AFC after a disappointing 2024 season where they missed the playoffs with a 7-10 record. One of the biggest challenges facing the Colts is rebuilding the team. To address this, the roster has focused on revamping the offense to provide quarterback Daniel Jones with better options and improve their chances of winning more games. Key players on the roster include Jonathan Taylor, George Pickens, Kenneth Murray Jr., Donovan Wilson, CeeDee Lamb, and Brandon Aubrey. The Colts will have a busy season ahead, where they’ll need to prove themselves in upcoming games against Cleveland, Denver, and Pittsburgh. Improving their offensive chemistry is crucial this season as they strive for a successful rebuild. Their current record is 6-7-1.

These are the players on the team’s injury list: None. Despite not having any seriously injured players, the San Francisco team has its full roster available for this game, although we may see some roster rotation and players may be rested.

The 49ers quarterback begins a new season with the sole mission of regaining the form he showed last season and leading the team back to the playoffs. The San Francisco quarterback is the team’s offensive leader. His stats this season include 1,130 passing yards, 5 touchdown passes, and 2 interceptions, which have helped his team secure 2 wins so far. The game against the Colts will be a great test to further showcase the chemistry within the 49ers’ offense. The quarterback’s connection with Christian McCaffrey will be crucial for a successful season.

The San Francisco 49ers kicked off a new season in the AFC after a disappointing 2014 season where they missed the playoffs with a 7-10 record. One of the biggest challenges facing the 49ers is the significant change in their offensive lineup. With the departure of Ekeler and Allen, the team’s best wide receiver and running back positions were vacant, prompting the roster to revamp its offense and provide better options for their quarterback to win more games. Some of the notable additions to the team include Brock Purdy, Christian McCaffrey, Josh Palmer, Derwin James Jr., Asante Samuel Jr., and Cameron Dicker. The 49ers will have a challenging start to the season, facing Las Vegas, Carolina, and Pittsburgh. Therefore, improving the team’s offensive chemistry this season is crucial for a successful rebuild.

Welcome to the live broadcast of the San Francisco 49ers vs. Indianapolis Colts game, Week 16 of the 2025 NFL Regular Season. The game will take place at Lucas Oil Stadium at 7:15 PM. My name is Carlos, and I’ll be your host for this game. We’ll bring you pre-game analysis, score updates, and live news right here on VAVEL.